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Coordinated epigenetic dysregulation of CNR1 and FAAH genes drives endocannabinoid system dysfunction in anorexia nervosa.

J Eat Disord · 2025 · PMC12771889 · PMID 41310856

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Notably, methylation at CNR1 CpG Position 2 showed a strong and highly significant negative correlation with methylation at all FAAH CpG sites ( p < 0.05) (Fig. 2 ), indicating that higher methylation levels in CNR1 correspond to lower methylation levels in FAAH gene.

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