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On the history, synthesis, and medicinal use of cantharidin, LB-100, and their analogs.

RSC Med Chem · 2026 · PMC12772682 · PMID 41502824

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As such, there may be significant potential for using cantharidin derivatives to target these enzymes in much the same way that LB-100 has for PP2A, though this will require new chemistries to access C1/C2 substituted analogs.

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