Sequential structural rearrangements at the PAM-distal site of a type I-F3 CRISPR-Cas effector enabling RNA-guided DNA transposition.

Nucleic Acids Res · 2026 · PMC12774636 · PMID 41495894

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highly significantno p-value reported

Although transposition for targeting the hflK gene is less efficient, the fact that DNA integration into the target with several mismatches at the PAM-proximal region occurs is highly significant from the perspective of the functional relevance of the CAST system (see “Discussion” section).

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