highly significantp < 0.01
Intergroup differences were assessed for significance via t-tests: * denotes a significant difference (p < 0.05), ** a highly significant difference (p < 0.01), # a significant difference (p < 0.05) and ## a highly significant difference (p < 0.01). * indicates a difference analysis with the PBS group as the control group, and # indicates a difference analysis with the pNZ8149/NZ group as the control group.