Neuron-specific WDR5 epigenetically upregulates ARID5B to impair GABAergic synaptic transmission and promotes epileptogenesis.

Theranostics · 2026 · PMC12775672 · PMID 41510154

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a nonsignificant trendno p-value reported

Behavioral analysis revealed that OICR-9429 treatment significantly prolonged the latency to the first generalized tonic‒clonic seizure (GTCS) in a dose-dependent manner, with a nonsignificant trend toward reduced mortality (Figure 2 D-F).

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