Pharmacokinetic and pharmacodynamic characterization of gepotidacin against <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> in a neutropenic mouse thigh infection model.

Antimicrob Agents Chemother · 2026 · PMC12777569 · PMID 41347519

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a nonsignificant trendno p-value reported

A nonsignificant trend was observed whereby some isolates with more growth in vehicle-treated mice required higher fAUC/MIC ratios for efficacy ( Fig. 2 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Pharmacokinetic and pharmacodynamic characterization of gepotidacin against &lt;i&gt;Escherichia coli&lt;/i&gt; and &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt; in a neutropenic mouse thigh infection model.

The sentences

Pharmacokinetic and pharmacodynamic characterization of gepotidacin against <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> in a neutropenic mouse thigh infection model.