Additionally, the meta-analysis for cardiovascular diseases revealed a similarly strong association, with a mean difference of 2.85 (95% CI: 2.64–3.07, P < .00001), and a Z statistic of 27.15 ( P < .00001), indicating a highly significant difference in the incidence of cardiovascular diseases between syphilis patients and controls.
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Long-term health effects of syphilis in cardiovascular diseases and neurological diseases: A systematic review and meta-analysis.
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