highly significantp < 0.01
The inter‐group comparisons between orthodontically treated and untreated sites revealed highly significant differences ( p < 0.01), except in NLRP3 −/− mice at 7 days ( p = 0.07) and 21 days ( p = 0.88), indicating milder histological changes in this genotype in the course of orthodontic treatment (Figure 1d ).