Replication stress-inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors.

Elife · 2026 · PMC12779267 · PMID 41498327

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an increasing trendno p-value reported

Moreover, we applied Monocle to reconstruct the transformation trajectories from normal mammary cells to tumor cells in the BRCA1 mutation carrier and found that the levels of replication stress showed an increasing trend during the process of LP transformation into tumor cells ( Figure 1C , Figure 1—figure supplement 1B ).

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