Contributions of major tau kinase activation and phospho-tau accumulation to cortical and hippocampal tangle formation and cognition in older adults.

In samples from the DLPFC of MAP participants, the immunodensities of total kinase forms of CDK5, GSK3 and ERK1/2 (i.e., regardless of their phosphorylation status) showed no or marginally significant associations with tau (phospho)peptide amounts ( Fig. 1C and Supplementary File , Fig.

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