Bioactive glass nanoparticles induce intrinsic p53-dependent apoptosis and promote genomic instability via ROS overproduction and mitochondrial depolarization in triple-negative breast cancer cells.

Sci Rep · 2026 · PMC12780067 · PMID 41495194

Europe PMC DOI

hedged sentence

0.0010

closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp < 0.001actually significant

This oxidative burst was quantitatively confirmed by a highly significant increase ( p < 0.001) in the fluorescence intensity of the ROS-sensitive probe 2′,7′-DCFH-DA, which fluoresces upon oxidation by ROS.

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