Global Epidemiological Transition of Atrial Fibrillation/Flutter (1990-2021): Multidimensional Burden Dynamics and Socioeconomic Health Gradients Across 204 Countries and Territories.

Rev Cardiovasc Med · 2025 · PMC12781011 · PMID 41524042

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an increasing trendno p-value reported

The ASDR generally showed an increasing trend [AAPC = 0.106 (95% CI: 0.031–0.181)], decreasing between 2018 and 2021 [APC = –0.878 (95% CI: –1.218 – –0.536)], and increasing between 1990 and 1995 [APC = 0.665 (95% CI: 0.517–0.813)], 1995 and 2003 [APC = 0.162 (95% CI: 0.083–0.242)], and 2012 and 2018 [APC = 0.365 (95% CI: 0.225–0.506)] ( Supplementary Table 9 ; Fig. 5 G).

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a decreasing trendno p-value reported

The ASIR generally showed a decreasing trend [AAPC = –0.027 (95% CI: –0.034 – –0.02)], but there were periods of local increasing trends, specifically rising between 2001 and 2004 [APC = 0.348 (95% CI: 0.297–0.4)], 2015 and 2019 [APC = 0.384 (95% CI: 0.359–0.409)], and 2019 and 2021 [APC = 0.787 (95% CI: 0.735–0.838)], while decreasing between 1990 and 1995 [APC = –0.331 (95% CI: –0.344 – –0.318)], 1995 and 2001 [APC = –0.192 (95% CI: –0.205 – –0.18)], and 2004 and 2010 [APC = –0.307 (95% CI: –0.318 – –0.296)]( Supplementary Table 9 ; Fig. 5 E).

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