YAP-TEAD regulates the super-enhancer network to control early surface ectoderm commitment.

Nucleic Acids Res · 2026 · PMC12781878 · PMID 41505091

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a pronounced trendno p-value reported

Furthermore, the analysis of D7SPSE-connected genes using D0 and D7 RNA-seq data indicates a pronounced trend for genes under D7SPSE regulation to be preferentially expressed in surface ectoderm cells (D7) as opposed to hESCs (D0), as illustrated in Fig. 2D .

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