Platelet-mediated activation of perivascular mast cells triggers progression of sepsis to septic shock in mice.

On an ordinary scale progressing from control to sepsis to septic shock, Chymase levels displayed a strong and highly significant positive correlation (Spearman’s coefficient r s = 0,54, p = 3×10 -7 ), Ang 1 a significant negative correlation (r s = -0,27, p = 0,014), and Ang2 a weak but significant positive correlation (r s =0,23, p = 0,053) with sepsis severity (Supplemental Fig. 4 ).

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