Mechanics of blunting of actin-myosin interaction dynamics by the actinopathy-causing mutation E334Q in cytoskeletal γ-actin.

The F – V relation obtained with the heterofilaments shows that the depressing effects of the mutation on F 0 * were only partially attenuated but still highly significant: in this case F 0 * was 11.9 ± 1.7 pN (Fig. 2 C , Table 2 ), 34% smaller than WT γ‐actin.

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