Elucidating the susceptibility genes between insomnia and migraine by integrating genetic data and transcriptomes.

J Headache Pain · 2026 · PMC12784587 · PMID 41495640

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marginally significantno p-value reported

Bi-directional MR indicated a potential causal risk of insomnia to MA at a marginally significant level, but migraine, including MA and MO, was not causally associated with the risk of insomnia.

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marginal significanceno p-value reported

Our primary results indicated that insomnia may cause MA at a marginal significance level (IVW, P : 0.075).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.