highly significantp < 0.0001
A direct statistical comparison of genotype–phenotype profiles ( Supplementary Table S1 ) confirmed several highly significant associations. mecA -positive isolates exhibited a 16-fold increase in oxacillin MIC (median 4.00 vs. 0.25 μg/mL, p < 0.0001) and a 5.6-fold increase in penicillin MIC.