AHR Deficiency Exacerbates Hepatic Cholesterol Accumulation via Inhibiting Bile Acid Synthesis in MAFLD Rats.

Moreover, we also observed a decreasing trend in hepatic Apob expression in AHR-deficient rats.

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Since HFHFrHCD could increase hepatic TG content in the AHR knockout group, we also presented the genes related to lipid uptake and lipoproteins, key regulators of Very Low-Density Lipoprotein (VLDL) assembly and secretion, and De Novo lipogenesis in the RNA-sequencing data ( Figure S3 ), where an increasing trend in the genes of De Novo lipogenesis was observed, but without a statistically significant difference.

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