Barely Significant
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Vaping Troubles: Exploring the Link Between E-Cigarettes and Oral Lesions in India's Urban Youth.

J Pharm Bioallied Sci · 2025 · PMC12788529 · PMID 41523055

1
hedged sentence
0.0780
closest p · 1.6× alpha
0.0780
boldest claim

The sentences

a nonsignificant trendP = 0.078so close (0.05 < p ≤ 0.1)
These findings corroborate laboratory studies demonstrating that nicotine concentrations ≥5 mg/mL significantly increase cytotoxicity in oral keratinocytes.[ 8 ] Interestingly, while flavored e-liquids showed a nonsignificant trend toward higher risk (aPR = 1.60, P = 0.078), this may reflect the limited power to detect effects of specific flavoring compounds, which have shown variable toxicity profiles in in vitro studies.[ 9 ] C ONCLUSION This study provides compelling evidence linking e-cigarette use with oral lesions among urban Indian youth, even after controlling for potential confounders.

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