Hotspot mutations in HER2 interfaces destabilize structure, causing breast cancer treatment failure.

Oncogene · 2026 · PMC12795759 · PMID 41392272

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an increasing trendno p-value reported

Analyzing the total number of interactions with stabilized dimers revealed an increasing trend for H2-WT and S305C, while G309A and S310Y mutants showed a reverse trend (Supplementary Fig.

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a decreasing trendno p-value reported

However, a decreasing trend in the negative values for G309A, S310Y, and S310F indicated thermodynamically unfavorable homodimers for these mutants (Fig. 1K ).

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