Barely Significant
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Novel syngeneic model of anti-mouse CLDN18.2 CAR -T therapy for gastric cancer demonstrates a synergy with TGF-β and PD-L1 inhibitors.

Mol Ther Oncol · 2026 · PMC12796737 · PMID 41537163

Europe PMCDOI
2
hedged sentences
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closest p · 0.0× alpha
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boldest claim

The sentences

highly significantp < 0.0001actually significant
Post hoc pairwise t tests using CAR-T monotherapy as the reference revealed no significant difference for CAR-T + aPD-L1, a statistically significant reduction for CAR-T + TGF-βi ( p < 0.05), and a highly significant effect for the CAR-T + dual TGF-βi/aPD-L1 ( p < 0.0001).

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a nonsignificant trendno p-value reported
We observed a nonsignificant trend for CAR-T-induced upregulation of the average mRNA expression level of Cd274 ( Figures S7 and S8 ; Table S2 ).

also in 5,406 other papers

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