These findings highlight two critical considerations: (1) rigorous multiple testing correction is essential in genetic epidemiology to mitigate false-positive results from extensive subgroup analyses; and (2) observed subgroup associations, particularly those with borderline significance, should be interpreted as hypothesis-generating rather than definitive evidence.
← all excerpts
The rs34416841 polymorphism in the Alu element of the circSirt1 flanking intron is associated with an increased risk of myocardial infarction.
1
—
—