Immune checkpoint expression in mucosal-associated invariant T cells is stimulus-dependent.

J Leukoc Biol · 2025 · PMC12798798 · PMID 41351541

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a nonsignificant trendno p-value reported

coli appeared to provide an intermediate transcriptional signature, with significant upregulation of Ctla4 , Pdcd1 , Cd274 , Havcr2 , Lag3 , and Klrc1 with a nonsignificant trend for Vsir .

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highly significantno p-value reported

This gave us the most highly significant DE genes for each stimulus represented by more than 1 study, amounting to 54 genes for 5-OP-RU, 30 genes for cytokine stimulation, 45 genes for E. coli , and 61 genes for antiCD3-CD28 ( Fig. 2 , Table S5 ).

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