Putative new biomarkers for renal transporter-mediated drug-drug interactions: Characterization as substrates of organic cation transporter 2, multidrug and toxin extrusion protein 1, and other important drug transporters.

Drug Metab Dispos · 2025 · PMC12799524 · PMID 41072274

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25 , 30 , 36 In MDCK cells, we observed a highly significant basal to apical transport in MDCK-OCT2-MATE1 cells and a reduction of intracellular 4-guanidinobutanoic acid when MATE1 was overexpressed ( Fig. 4 E).

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