Comparative effectiveness of remineralization agents on attachment-associated enamel demineralization in clear aligner patients: A 6-Month DIAGNOdent-Based controlled clinical trial.

Primary outcome analysis The primary analysis using a linear mixed-effects model (LMM), adjusting for baseline attachment number as a covariate, revealed a highly significant main effect of GROUP on the change in DIAGNOdent scores from baseline to 6 months (F [ 3 , 35 ] = 438.4, p < 0.001).

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