Cell-type-specific DNA methylation dynamics in the prenatal and postnatal human cortex.

Consistent with our previous results, we found a small but highly significant enrichment of dDMPs becoming hypomethylated with cortex development ( n = 28,780 [56.5%], p = 1.61 × 10 −191 ) with the mean effect size being significantly greater for hypomethylated dDMPs than hypermethylated dDMPs (change in DNA methylation [%] per week: hypermethylated dDMPs = 1.03, hypomethylated dDMPs = −1.53, t test p < 1 × 10 −320 , Figure S3 ).

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