DNA prime and peptide boost immunization elicits robust neoantigen-specific CD8 <sup>+</sup> T cell responses and therapeutic protection in mouse tumor models.

Oncoimmunology · 2026 · PMC12802984 · PMID 41521424

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highly significantno p-value reported

Interestingly, while αPD-1 monotherapy had minimal antitumor effect, the combination therapy induced a highly significant tumor rejection in 60% (6/10) of the mice ( Figure 5a,b ).

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DNA prime and peptide boost immunization elicits robust neoantigen-specific CD8 &lt;sup&gt;+&lt;/sup&gt; T cell responses and therapeutic protection in mouse tumor models.

The sentences

DNA prime and peptide boost immunization elicits robust neoantigen-specific CD8 <sup>+</sup> T cell responses and therapeutic protection in mouse tumor models.