Evaluating transportability of in vitro cellular models to in vivo human phenotypes using gene perturbation data.

For example, we observed some evidence (albeit borderline significant) of enrichment for the chondrocyte-gene set for height pLoF evidence, but found limited evidence when modelling directionality and continuous effect sizes in GPAT that chondrocyte proliferation is a transportable model for height (beta = 0.007 cm; P -value = 0.42).

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