Efficient synthesis, dual anti-tubercular and antioxidant activity of triazole-acetophenone derivatives: enhanced efficacy <i>via</i> esterification and quantum mechanical validation of CYP121 binding.

RSC Adv · 2026 · PMC12805941 · PMID 41550807

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highly significantno p-value reported

This interaction is highly significant, as Gln385 is known to be a pivotal residue, experimentally validated to stabilize the natural substrate cyclodityrosine and other CYP121 inhibitors.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Efficient synthesis, dual anti-tubercular and antioxidant activity of triazole-acetophenone derivatives: enhanced efficacy &lt;i&gt;via&lt;/i&gt; esterification and quantum mechanical validation of CYP121 binding.

The sentences

Efficient synthesis, dual anti-tubercular and antioxidant activity of triazole-acetophenone derivatives: enhanced efficacy <i>via</i> esterification and quantum mechanical validation of CYP121 binding.