Microglial Rack1 Deficiency Alleviates Alzheimer's Disease Pathology through Enhancing IGF1-Mediated Astrocytic Phagocytosis.

As shown in Figure 3 A,B , the conditional loss of Rack1 in microglia significantly reduced Aβ plaque accumulation in the hippocampal dentate gyrus (DG) and prefrontal cortex (PFC) regions, with a decreasing trend detected in the hippocampal CA1 region.

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Notably, we found that the number of astrocytes in the hippocampal DG and CA1 regions was significantly increased in Rack1 cKO/AD mice when compared with Rack1 WT/AD mice, with an increasing trend also detected in the PFC region ( Figure 4 A,B ).

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