Rtf1-dependent transcriptional pausing regulates cardiogenesis.

Flavopiridol treatment caused a small but highly significant increase in promoter-proximal pausing in an Rtf1-deficient background ( Figure 8a ), with 87.1% of genes with significantly altered PRR values displaying an increase in PRR in flavopiridol-treated rtf1 morphants compared to untreated rtf1 morphants ( Figure 8c ).

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