CHAMP1 is an essential regulator for human myoblast fusion and muscle development.

Nat Commun · 2026 · PMC12808755 · PMID 41540007

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highly significantno p-value reported

Supporting this notion, none of CHAMP1’s known interactors, including CBX1/3/5, MAD2L2 and POGZ—proteins with well-established roles in chromosome alignment and DNA repair 34 —were identified in our initial fusion screen where CHAMP1 stood out as a highly significant hit.

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