Comparative evaluation of the prediction accuracy of AlphaFold and ESMFold for monomeric and dimeric proteins.

NAR Genom Bioinform · 2026 · PMC12809598 · PMID 41551928

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highly significantno p-value reported

For the RMSD metric, no significance was observed between AlphaFold2 and AlphaFold3, while a highly significant difference was detected between the AlphaFold models and ESMFold.

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