Integrative analysis across metagenomic taxonomic classifiers: A case study of the gut microbiome in aging and longevity in the Integrative Longevity Omics Study.

However, this was observed for only 2 species in our study that became borderline significant via the correlated meta-analysis approach due to minimal differences introduced by the different FDR calculations within methods.

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These were generally taxa with borderline significance in the individual tests from both profiles (i.e., FDR q-values slightly greater than 0.05), where the concordance in associations across profiles resulted in a significant meta-analyzed FDR q-value.

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