Furthermore, we observed a decreasing trend toward ~10%–15% engraftment at Months 2, 3, and 4 after transplantation, indicating a loss of competitiveness and intrinsic HSC defect in Rps19 mutants (Figure 2O ).
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<i>Rps19</i> <sup>R67∆</sup> mutation creates a model of Diamond-Blackfan anemia and reveals downstream mediators of p53 pathway.
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