Persistent effects of early-life arsenic exposure in <i>Caenorhabditis elegans</i>.

Interestingly, a highly significant (log 2 FC −1.56, p -value 4 × 10 −44 ) transcript downregulated in the high exposure group identified in the metabolic pathways KEGG pathway is pck-1 (phosphoenolpyruvate carboxykinase), potentially suggesting a shift away from oxidative metabolism 43 and supporting previous findings of a Warburg-like effect in worms exposed to arsenic. 16 Due to a low number of upregulated transcripts in the 10% LC 10 group 8 days after exposure (only three), only the upregulated LC 10 8 days post-exposure list of transcripts was analyzed in DAVID.

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