Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease.

Additionally, though not quite statistically significant after correcting for multiple testing, HLA‐DPB1*06:01 was associated with a lower middle frontal LB count (Multiplicative effect = 0.40, p = 1.80 × 10 −4 , Supplementary Fig. 1 ), HLA‐DRB1*11:01 was linked to a lower Thal amyloid phase (≥3: 44.7% vs 74.8%, OR 0.34, p = 1.56 × 10 −4 ), HLA‐DPB1*06:01 was associated with a lower inferior parietal LB count (multiplicative effect = 0.41, p = 6.33 × 10 −4 , Supplementary Fig. 1 ), and HLA‐B*15:01 was linked to an increased risk of diffuse LBD (85.7% vs 67.2%, OR 3.43, p = 7.58 × 10 −4 ).

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