Sex-based differences in outcomes after transcatheter aortic valve implantation: a systematic review and meta-analysis of randomised trials.

However, findings from the Italian OBSERVANT Registry indicate that permanent atrioventricular block is less common in female than male TAVI patients (9.6% vs 17.2%), with a trend toward significance for female sex as a protective factor (p=0.05; OR: 0.61). 38 The results are even stronger in studies where CoreValve use predominates, such as the meta-analysis by Zhao et al . 31 One proposed explanation for the higher PPI incidence in men is the use of larger prostheses, as men generally have larger valve annuli.

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This result is highly significant and consistent across studies, indicating minimal heterogeneity.

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