indicated that abnormal expression of methylation-associated enzymes such as DNMT3A and DNMT3B might be significant diagnostic tools rather than indicators of ITP activity [ 30 ]; Another study suggested an important role for DNMT3B rs2424913 Single-nucleotide polymorphisms (SNPs) in altering methylation phenotype and contributing to the pathogenesis of chronic ITP [ 31 ]; Aberrant methylation-related genes such as CD70 have also been involved in ITP, elevated expression of CD70 might be caused by its hypomethylated promoter region and can facilitate the survival of T and B lymphocytes, promote apoptosis of platelets, and enhance secretion of IFN-γ, finally accelerating the progress of ITP [ 32 ].
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