The study revealed that NFE2L2 deficiency leads to reduced infiltration of macrophages expressing M2-associated markers and exhausted CD8+ T cells within tumors, while macrophages expressing M1-associated markers exhibit an increasing trend (Fig. 5 D).
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Metabolic-transcriptional rewiring by NFE2L2 promotes M2 macrophage polarization and anti-PD-L1 resistance in glioma.
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