NVP-HSP990 only modestly (~1-fold) reduced the final level of RV replication when administered during the course of RV infection (−1 ~ 0 h p.i.), suggesting that it is not highly effective at blocking RV entry into host cells; on the contrary, NVP-HSP990 administration after RV infection and during the whole process of cultivation (0 ~ 20 h p.i.) resulted in a highly significant, nearly 100-fold inhibitory effect, and exhibited a synergistic effect with NVP-HSP990 administration during the course of RV infection (−1 ~ 0 h p.i.) ( Fig. 2B and C ).
← all excerpts
A small-molecule HSP90 inhibitor, NVP-HSP990, alleviates rotavirus infection.
1
—
—