Monitoring ADAMTS-13 conformation in immune-mediated thrombotic thrombocytopenic purpura: toward personalized management.

There was also a nonsignificant trend for a longer time with an open ADAMTS-13 conformation in group 2 than that in group 1 (0.6 [IQR, 0.4-0.7] vs 0.2 [IQR, 0.1-0.5], respectively; P = .1427).

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Although not statistically significant, the higher proportion of open ADAMTS-13 conformation in group 2, where biological remission between episodes was less frequently observed, may suggest a possible trend toward an association between a more persistent open conformation during remission and a higher risk of relapse, which warrants further investigation in larger cohorts. 3.3 Association between normal ADAMTS-13 activity (≥50 IU/dL) and ADAMTS-13 conformation Further, we investigated the risk of relapse in patients with complete ADAMTS-13 remission (ie, activity of ≥50 IU/dL), by comparing ADAMTS-13 conformation from samples of patients of both groups.

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