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Piezo1 dictates K<sup>+</sup> homeostasis through coordinated regulation of the ubiquitin ligase Kelch-like 3 in RBCs and the kidney.

Proc Natl Acad Sci U S A · 2026 · PMC12818455 · PMID 41533447

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an increasing trendno p-value reported
The ratio of cleaved to uncleaved ENaCγ, an indicator of ENaC activity, showed an increasing trend in KLHL3-KI mice ( Fig. 4 B ), which may be attributable to the increased circulating aldosterone levels in this model.

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