Oligosaccharyltransferase (OST) complex inhibition effectively treats rodent and human prions.

PLoS Pathog · 2026 · PMC12818742 · PMID 41525337

Europe PMC DOI

hedged sentence

0.2250

closest p · 4.5× alpha

0.2250

boldest claim

The sentences

fell short of significancep ~ 0.225not close (p > 0.1)

a slight trendno p-value reported

We did observe a slight trend in the NGI-1 treated cells toward reduced total PrP puncta area (~0.8% vs ~ 2% in control conditions), however this trend fell short of significance (p ~ 0.225).

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