SEPAR enables spatial metagene discovery and associated molecular pattern characterization in spatial transcriptomics and multi-omics datasets.

Commun Biol · 2025 · PMC12820152 · PMID 41372421

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highly significantno p-value reported

Pattern 9, localized in the developing muscle tissue surrounding the E15.5 mouse brain, exhibits highly significant enrichment of E-box motifs (CANNTG) (Supplementary Fig. 31 ), which are canonical binding sites for myogenic regulatory factors (MRFs) 68 .

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