Conversely, the downregulation of critical signaling pathways like TGF-β, Notch, and Wnt is highly significant, as these pathways are deeply implicated in male sex determination, testis development, and spermatogonial stem cell maintenance (Fig. 3 M-N) [ 43 – 45 ].
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Deciphering the gonadal cell atlas of Monopterus albus and cell fate during sex reversal based on single-cell RNA sequencing.
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