Association of different serum creatinine trajectories with 28-day mortality in patients with acute kidney injury on chronic kidney disease: based on the MIMIC-IV database.

Through GBTM analysis, five distinct trajectory groups were identified: Group G1 ( n = 1762, 22.4%) with Scr levels maintained at approximately 1 and showing a stable trend (Scr low-stable group); Group G2 ( n = 915, 11.7%) with baseline Scr levels above 8 and showing a decreasing trend (Scr high-decreasing group); Group G3 ( n = 2017, 25.7%) with Scr levels maintained at approximately 1.3–1.5 and showing a stable trend (Scr moderate-low stable group); Group G4 ( n = 1707, 21.7%) with Scr levels maintained at approximately 2 and showing a stable trend (Scr moderate-stable group); and Group G5 ( n = 1451, 18.5%) with Scr levels maintained at approximately 4 and showing a stable trend (Scr moderate-high stable group).

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