Ω-Loop mutations control dynamics of the active site by modulating the hydrogen-bonding network in PDC-3 β-lactamase.

Elife · 2026 · PMC12823066 · PMID 41562583

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not as significantno p-value reported

The G214R, E219A, E219K, and Y221A variants exhibit RMSD values that are intermediate between the wild-type and the most flexible variants, indicating that these amino acid substitutions have a moderate effect on the structural stability of the protein’s conformation, that is, not as significant as the V211A and E219G substitutions.

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