Three years later: tracking bothersome symptoms and impacts for people with early Parkinson's disease.

(Female, age 63) Comparing baseline to year 3, highly significant physical impacts included greater effort to do usual activities (36% vs. 100%, p < 0.001) and greater physical discomfort (34% at year 1 increasing to 94% by year 3, p < 0.001), most commonly affecting walking and exercise, as well as increased trouble with gripping/opening (28% vs 66%, p < 0.01), standing (16% vs 66%, p < 0.001), getting up (16% vs 59%, p < 0.001), climbing stairs (16% vs 56%, p < 0.01), tripping/falling (18.7% vs. 46.9%, p < 0.01), eating/drinking (59% vs. 81%, p < 0.05), and dressing (41% vs. 72%, p < 0.01).

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