Comparing Combined Non-ablative Fractional Laser and Radiofrequency Microneedling Versus Non-ablative Fractional Laser Alone for Acne Scar Treatment: A Meta-Analysis.

Cureus · 2025 · PMC12824548 · PMID 41583246

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hedged sentences

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closest p · 1.0× alpha

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boldest claim

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borderline significantp=0.05actually significant

Subgroup analysis indicated a borderline significant benefit for the FMR+ablative fractional laser (AFL) combination (OR: 2.76, 95% CI: 0.99-7.71, p=0.05) but not for FMR+non-ablative fractional laser (NAFL).

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borderline significanceno p-value reported

Despite the lack of significance for the overall treatment effect when combined with both AFL and NAFL, the data set from the AFL group does deserve closer scrutiny regarding the suggestive borderline significance of the treatment effect.

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